Dr. Klar Yaggi is a professor of medicine and the Vice Chief for Research in the Yale Section of Pulmonary, Critical Care, and Sleep Medicine. He also serves as the Director of the Yale Centers for Sleep Medicine.
His research employs translational methods applied to sleep science, circadian biology, and respiratory neurobiology to investigate the mechanistic pathways between sleep deficiency (sleep deprivation, noncircadian wakefulness/sleep, and impaired sleep quality/architecture due to insomnia/sleep-disordered breathing) and cardio-metabolic disease, substance use disorders, cognitive impairment, and mental illness.
His research approach integrates physiology, clinical medicine, and novel biostatistical methods in epidemiologic designs, including large, multicenter observational cohort studies of adult populations and mechanistic randomized controlled trials.
His work has 1) informed the prognostic implications of the phenotypic expression of sleep disorders through polysomnographic physiologic traits and biomarkers and 2) examined the impact of interventions targeting sleep deficiency that may help to improve markers of disease and health outcomes.
His lab, the Yale Translational Sleep, Circadian, and Respiratory Neurobiology Research Center on Yale’s West Campus, provides infrastructure for supporting multi-disciplinary translational sleep research.
He is committed to mentoring and training the next generation of scientists, which he considers the most rewarding aspect of his professional work, and he has successfully mentored postdoctoral fellows and junior faculty to independence.
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